Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses IZI-BB
Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses IZI-BB

Dr. Jan Kiebist

 

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Academic CV
Since 2018

Post-Doc at the Fraunhofer IZI-BB, Project Group PZ-Syn, Senftenberg
2013 - 2018

Research associate at the Institute of Biotechnology, FG Enzyme Technology, BTU Cottbus-Senftenberg, Senftenberg
2013 Department R&D DSAR Drug Disposition ICMS, Sanofi-Aventis Deutschland GmbH, Frankfurt/Main
2011 - 2012

Institute for Radiopharmacy, Helmholtz Centre Dresden-Rossendorf, Dresden

Education
2014 - 2018 PhD thesis in biology (Prof. M. Hofrichter, TU Dresden, Prof. K. Scheibner, BTU Cottbus-Senftenberg): "Oxyfunctionalization of pharmaceutically relevant structures by non-specific peroxygenases of family I from Dikarya fungi"
2013

Master thesis (Prof. K. Scheibner, BTU Cottbus-Senftenberg, Dr. J. Atzrodt, Sanofi-Aventis Deutschland GmbH): "Preparative application of peroxygenases and hydrolases from basidiomycetes in the synthesis of drug metabolites".
2012 - 2013

Master's degree in chemistry at BTU Cottbus-Senftenberg
2012 Bachelor thesis (Prof. K. Salchert, HS Lausitz, Dr. R. Löser, Helmholtz-Zentrum Dresden-Rossendorf): "Establishment of a fluorimetric activity assay for lysyl oxidase".
2012

Bachelor study chemical engineering at the Lausitz University of Applied Sciences
2008 - 2012 Military service
2004 Abitur
Prizes and Scholarships
2012

BASF Process Engineering Award
Memberships
Society of German Chemists e.V.
Lausitzer Biotech e.V.
1. FC Union Berlin e.V.

  • Gomez de Santos, P., González-Benjumea, A., Fernandez-Garcia, A., Aranda, C., Wu, Y., But, A., Molina-Espeja, P., Maté, D. M., Gonzalez-Perez, D., Zhang, W., Kiebist, J., Scheibner, K., Hofrichter, M., Świderek, K., Moliner, V., Sanz-Aparicio, J., Hollmann, F., Gutiérrez, A., & Alcalde, M. (2023). Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids. Angewandte Chemie (International Ed. In English), 62(9), e202217372. https://doi.org/10.1002/anie.202217372
  • Walter, R. M., Zemella, A., Schramm, M., Kiebist, J., & Kubick, S. (2022). Vesicle-based cell-free synthesis of short and long unspecific peroxygenases. Frontiers in Bioengineering and Biotechnology, 10, 964396. https://doi.org/10.3389/fbioe.2022.964396
  • König, R., Kiebist, J., Kalmbach, J., Herzog, R., Schmidtke, K.-U., Kellner, H., Ullrich, R., Jehmlich, N., Hofrichter, M., & Scheibner, K. (2022). Novel Unspecific Peroxygenase from Truncatella angustata Catalyzes the Synthesis of Bioactive Lipid Mediators. Microorganisms, 10(7). https://doi.org/10.3390/microorganisms10071267
  • Kellner, H., Friedrich, S., Schmidtke, K.-U., Ullrich, R., Kiebist, J., Zänder, D., Hofrichter, M., & Scheibner, K. (2022). Draft Genome Sequence of Truncatella angustata (Anamorph) S358. Microbiology Resource Announcements, 11(7), e0005222. https://doi.org/10.1128/mra.00052-22
  • Babot, E. D., Aranda, C., Kiebist, J., Scheibner, K., Ullrich, R., Hofrichter, M., Martínez, A. T., & Gutiérrez, A. (2022). Enzymatic Epoxidation of Long-Chain Terminal Alkenes by Fungal Peroxygenases. Antioxidants (Basel, Switzerland), 11(3). https://doi.org/10.3390/antiox11030522
  • Schramm, M., Friedrich, S., Schmidtke, K.-U., Kiebist, J., Panzer, P., Kellner, H., Ullrich, R., Hofrichter, M., & Scheibner, K. (2022). Cell-Free Protein Synthesis with Fungal Lysates for the Rapid Production of Unspecific Peroxygenases. Antioxidants (Basel, Switzerland), 11(2). https://doi.org/10.3390/antiox11020284
  • Hofrichter, M., Kellner, H., Herzog, R., Karich, A., Kiebist, J., Scheibner, K., & Ullrich, R. (2022). Peroxide-Mediated Oxygenation of Organic Compounds by Fungal Peroxygenases. Antioxidants (Basel, Switzerland), 11(1). https://doi.org/10.3390/antiox11010163
  • Kiebist, J., Schmidtke, K.-U., Schramm, M., König, R., Quint, S., Kohlmann, J., Zuhse, R., Ullrich, R., Hofrichter, M., & Scheibner, K. (2021). Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases. Journal of Fungi (Basel, Switzerland), 7(9). https://doi.org/10.3390/jof7090752
  • Gomez de Santos, P., Hoang, M. D., Kiebist, J., Kellner, H., Ullrich, R., Scheibner, K., Hofrichter, M., Liers, C., & Alcalde, M. (2021). Functional Expression of Two Unusual Acidic Peroxygenases from Candolleomyces aberdarensis in Yeasts by Adopting Evolved Secretion Mutations. Applied and Environmental Microbiology, 87(19), e0087821. https://doi.org/10.1128/AEM.00878-21
  • Bello, S., Pérez, N., Kiebist, J., Scheibner, K., Sánchez Ruiz, M. I., Serrano, A., Martínez, Á. T., Feijoo, G., & Moreira, M. T. (2021). Early-stage sustainability assessment of enzyme production in the framework of lignocellulosic biorefinery. Journal of Cleaner Production, 285, 125461. https://doi.org/10.1016/j.jclepro.2020.125461
  • González-Benjumea, A., Marques, G., Herold-Majumdar, O. M., Kiebist, J., Scheibner, K., Del Río, J. C., Martínez, A. T., & Gutiérrez, A. (2020). High Epoxidation Yields of Vegetable Oil Hydrolyzates and Methyl Esters by Selected Fungal Peroxygenases. Frontiers in Bioengineering and Biotechnology, 8, 605854. https://doi.org/10.3389/fbioe.2020.605854
  • Ingenbosch, K. N., Quint, S., Dyllick-Brenzinger, M., Wunschik, D. S., Kiebist, J., Süss, P., Liebelt, U., Zuhse, R., Menyes, U., Scheibner, K., Mayer, C., Opwis, K., Gutmann, J. S., & Hoffmann-Jacobsen, K. (2021). Singlet-Oxygen Generation by Peroxidases and Peroxygenases for Chemoenzymatic Synthesis. Chembiochem : A European Journal of Chemical Biology, 22(2), 398–407. https://doi.org/10.1002/cbic.202000326
  • Babot, E. D., Aranda, C., Del Rı O, J. C., Ullrich, R., Kiebist, J., Scheibner, K., Hofrichter, M., Martı Nez, A. T., & Gutiérrez, A. (2020). Selective Oxygenation of Ionones and Damascones by Fungal Peroxygenases. Journal of Agricultural and Food Chemistry, 68(19), 5375–5383. https://doi.org/10.1021/acs.jafc.0c01019
  • Steinbrecht, S., Kiebist, J., König, R., Thiessen, M., Schmidtke, K.-U., Kammerer, S., Küpper, J.-H., & Scheibner, K. (2020). Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells. AMB Express, 10(1), 661. https://doi.org/10.1186/s13568-020-01064-w
  • Scheibner, K., Ullrich, R., Kiebist, J., Kellner, H., & Hofrichter, M. (2020). Unspezifische Peroxygenasen — Oxyfunktionalisierung außerhalb der Pilzhyphe. BIOspektrum, 26(1), 103–106. https://doi.org/10.1007/s12268-020-1338-x
  • Kiebist J., Hofrichter M., Zuhse R., Scheibner K. (2019). Oxyfunctionalization of pharmaceuticlas by fungal peroxygenases. Chapter 18 in Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients. Jenny Stanford Publishing Pte.Ltd. (Hrsg.), ISBN 9789814800808
  • Aranda, C., Municoy, M., Guallar, V., Kiebist, J., Scheibner, K., Ullrich, R., Del Río, J. C., Hofrichter, M., Martínez, A. T., & Gutiérrez, A. (2019). Selective synthesis of 4-hydroxyisophorone and 4-ketoisophorone by fungal peroxygenases. Catalysis Science & Technology, 9(6), 1398–1405. https://doi.org/10.1039/c8cy02114g
  • Aranda, C., Olmedo, A., Kiebist, J., Scheibner, K., Del Río, J. C., Martínez, A. T., & Gutiérrez, A. (2018). Selective Epoxidation of Fatty Acids and Fatty Acid Methyl Esters by Fungal Peroxygenases. ChemCatChem, 10(18), 3964–3968. https://doi.org/10.1002/cctc.201800849
  • Aranda, C., Ullrich, R., Kiebist, J., Scheibner, K., Del Río, J. C., Hofrichter, M., Martínez, A. T., & Gutiérrez, A. (2018). Selective synthesis of the resveratrol analogue 4,4′-dihydroxy- trans -stilbene and stilbenoids modification by fungal peroxygenases. Catalysis Science & Technology, 8(9), 2394–2401. https://doi.org/10.1039/C8CY00272J
  • Olmedo, A., Río, J. C. D., Kiebist, J., Ullrich, R., Hofrichter, M., Scheibner, K., Martínez, A. T., & Gutiérrez, A. (2017). Fatty Acid Chain Shortening by a Fungal Peroxygenase. Chemistry (Weinheim an Der Bergstrasse, Germany), 23(67), 16985–16989. https://doi.org/10.1002/chem.201704773
  • Kiebist, J., Schmidtke, K.-U., Zimmermann, J., Kellner, H., Jehmlich, N., Ullrich, R., Zänder, D., Hofrichter, M., & Scheibner, K. (2017). A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone. Chembiochem : A European Journal of Chemical Biology, 18(6), 563–569. https://doi.org/10.1002/cbic.201600677
  • Olmedo, A., Aranda, C., Del Río, J. C., Kiebist, J., Scheibner, K., Martínez, A. T., & Gutiérrez, A. (2016). From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase. Angewandte Chemie (International Ed. In English), 55(40), 12248–12251. https://doi.org/10.1002/anie.201605430
  • Kiebist, J., Holla, W., Heidrich, J., Poraj-Kobielska, M., Sandvoss, M., Simonis, R., Gröbe, G., Atzrodt, J., Hofrichter, M., & Scheibner, K. (2015). One-pot synthesis of human metabolites of SAR548304 by fungal peroxygenases. Bioorganic & Medicinal Chemistry, 23(15), 4324–4332. https://doi.org/10.1016/j.bmc.2015.06.035