Project | »PhysioInk«: Development of Sustainable Bio-Inks for the Production of Physiological Human Organ Structures

Process-Optimized Bioinks for Real-World 3D Bioprinting

3D bioprinting opens up new possibilities for the production of organs and tissues that are urgently needed, for example, in organ transplantation. However, existing bioinks have reached their limits: They are either easy to print or capable of replicating physiological tissue – yet both properties are essential for high-quality organ printing.

© Fraunhofer IZI-BB
Microscopic image of a fluorescence-labeled collagen matrix.

The Fraunhofer IAP and ISC have developed a patented process that stabilizes collagen and elastin using special macromolecules. These process-optimized bio-inks enable the precise replication of physiological tissue structures and are suitable for practical use in various printing processes.

Fraunhofer IZI-BB contributes to the development of physiological bioinks through interaction analyses, cell compatibility studies, and the monitoring of nutrient supply using optical microsensors.

Together with IMWS and ISC, two flagship applications are being realized:

Physiological heart tissue as a step toward functional implants for personalized, regenerative medicine.

Standardized colorectal cancer models for drug development.

With these innovative approaches, we are advancing the development of practical bioinks and shaping the future of 3D bioprinting.