Upconversion Nanotechnology

When classic fluorescence reaches its limits in terms of operating distance and stability, precisely controllable upconversion nanomaterials offer robust, multiplex-capable, and ratiometric measurement platforms, ranging from bioanalytical assays to integrable sensor systems. Optical analysis in scattering or strongly absorbing media poses significant challenges for signal stability and selectivity. Our upconversion technology converts invisible near-infrared light locally into visible or UV emission, enabling background-free, photostable, and deep tissue measurements. Controlled particle design allows excitation, emission, and lifetime to be precisely adjusted. Functionalizable surfaces enable integration into assays, sensor platforms, and optical devices from research to industrial applications. 

Characteristics and Benefits of the Technology

• Customized nanoparticle design: Controllable emission, lifetime, and particle size for imaging, sensor technology, and photochemical applications.
• Deeper tissue penetration with NIR excitation and low phototoxicity: High optical penetration depth and minimal background signal in scattering or biological media.
• Adaptive spectral light emission: Emission wavelengths from the UV to NIR range enable flexible detection and encoding strategies, even in multiplex processes.
• Precise surface functionalization: Stable coupling to biomolecules, polymers, or inorganic systems for specific targets.
• Background-free detection: High sensitivity and selectivity even in complex matrices such as blood, tissue, or environmental samples.

• Multimodal imaging capability: Can be combined with X-ray (CT), MRI, or other contrast methods for advanced diagnostic platforms.
• Extendable toward photochemistry and drug release: Light-driven reactions and controlled activation processes in material and bio applications.
• Ratiometric sensor technology: Quantitative analysis with high robustness against intensity fluctuations.